Feasibility Study of SOL (S-1,Oral Leucovorin,and Oxaliplatin) for Colorectal Cancer in China

Inclusion Criteria: * Advanced unresectable or recurrent colorectal cancer patients which meet the following criteria: * Willing to sign ICF * Could orally take investigational product * Pathology diagnosis is adenocarcinoma * Above 20 years * No previous treatment(including: radiotherapy,chemotherapy and immunotherapy) * For recurrent cases, if the patient had received adjuvant chemotherapy that didn't include S-1 and L-OHP in 180 days ago, he/she could be enrolled in * With target lesions with diameter which is longer than 1cm in spiral CT or MRI examination within 30 days * Lab test within 15 days meet following criteria * Hemoglobin higher than 9.0g/dL * Leukocyte higher than 12,000/mm3 * Neutrophil higher than 2,000/mm3 * PLT higher than 10.0 104/mm3 * Bilirubin lower than 1.5 times of upper limit of normal range * AST,ALT,ALP lower than 2.5 times of upper limit of normal range * Creatinine lower than upper limit of normal range When patient has liver metastasis or bone metastasis, the value of AST,ALT,ALP could be within 5 times of upper limit of normal range * ECOG 0 or 1 * Expected survival time more than 90 days Exclusion Criteria: * The patient who meet the following criteria should be excluded from this trial * Patients who have severe drug allergic history(including: platinum related drugs,5-FU,FT,LV,5-HT3 receptor antagonist) * Attended other clinical trial within 4 weeks * Received transfusion of blood,related products or G-CSF within 15 days * Received surgery within 4 weeks and the effect hadn't vanished * Have diarrhea * Have complication of active infection(infection caused fever higher than 38℃) * Have complication of poor controlled hypercalcemia,hypertension,diabetes * Have complication of severe ECG abnormal or other heart disease which will affect clinical treatment(including: cardiac dysfunction,myocardial infarction,angina) * Have complication of severe pulmonary disease(including:interstitial pneumonia,pulmonary fibrosis,severe emphysema) * Have complication of psychiatric disorder which will affect clinical treatment or have history of CNS disease * Have complication of active gastrointestinal bleeding * Have pleural effusion,ascites or pericardial effusion that need drainage * Have complication of multiple bone metastasis * Have severe complication(including:ileus,renal insufficiency,hepatic insufficiency,cerebrovascular disturbance) * Have brain metastasis or suspicious brain metastasis * Have active multiple primary cancer * Female patients who are in pregnancy or lactation and patients who are not willing to take contraception measures * Investigator judge not eligible to this trial