Rheumatoid arthritis (RA), affects between 0.3% and 1.0% of the population, it can lead to progressive joint destruction and severe disability. To date, two RA genetic susceptibility factors have been identified: HLA-DRB1-SE (Shared epitope) and PTPN22 620W alleles. The predictive value of the alleles for diagnosis of RA was previously investigated in cohorts of caucasians patients with early unclassified arthritis that showed restrained association between RA and HLA-SE. Despite the contribution of HLA to the overall genetic risk has been estimated to range from 30% to 50%, it has never been studied in the French west-Indian population.
Study Type
OBSERVATIONAL
Enrollment
200
After signed written consent, all patients have a clinic exam in order to assess the presence of eligibility criteria (Patient with Rheumatoid Arthritis that fulfil the ACR criteria of diagnosis)
Service de rhumatologie CHU de Fort-de-France
Fort-de-France, Martinique
Difference of distribution of HLA alleles in patients and in healthy controls
Time frame: 1 day
The association between the different HLA alleles among French West-Indian RA patients and the autoantibodies production.
Time frame: 1 day
The association between the different HLA alleles among French West-Indian RA patients and the radiological damage.
Time frame: 1 day
The association between the different HLA alleles among French West-Indian RA patients and the response to therapy
Time frame: 1 day
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