EASE MITRAL Expertise-based Assessment Study on Clinical Efficacy of Profile 3D in MITRAL Valve Annuloplasty

Inclusion Criteria: * Indicated for a surgical repair for moderate to severe mitral valve regurgitation at rest (level 2 or higher); * Willing to return to the hospital where the implantation originally occurred as part of the standard practice of care Exclusion Criteria: * Heavily calcified valves * Valvular retraction with severely reduced mobility * Active bacterial endocarditis * Already participating in another investigational device study, possibly leading to bias and jeopardizing the scientific appropriate assessment of the study endpoints; * Life expectancy of less than one year; * Pregnant or desire to be pregnant within 12 months of the study treatment; * Under 18 years or over 85 years of age.