Reducing Breast Cancer Recurrence With Weight Loss

Inclusion Criteria: * Diagnosis of breast cancer (stages I (≥1 cm), stage II, or stage IIIA, B, C excluding distant metastasis) diagnosed between 6 months and 5 years earlier; after initial therapies are completed, diagnosed between six months and five years earlier * BMI between 25 to 45 kg/m2 * Able to comply with all required study procedures and schedule Exclusion Criteria: * Serious medical condition or psychiatric illness * Inability to be moderately physically active * Obesity of known endocrine origin (e.g., untreated hypothyroidism, PCOS) * Currently enrolled in a weight loss program * Current use of weight loss medication or supplements * Previous surgical procedures for weight reduction * Planning weight loss surgery in the next 2 years. * 6+ months use of meds likely to cause weight gain or prevent weight loss * Planned surgical procedure that can impact the conduct of the study * Currently pregnant/breastfeeding * Planning to become pregnant within the next 2 years * Have plans to relocate from area within 2 years * Family relative or close friend is a trial staff member or a study participant * Any condition which in the opinion of the investigator makes the subject unsuitable for inclusion in this study