Oral Clonidine & Gabapentin: Improving Recovery and Pain Management After Outpatient With Major Orthopedic Surgery

Inclusion Criteria: * Patients scheduled to undergo arthroscopic joint surgery * Willingness and ability to sign an informed consent document * No allergies to clonidine, gabapentin, anesthetic or analgesic medications * 18 - 80 years of age * American Society of Anesthesiologists (ASA) Class I - III adults of either sex * Women of childbearing potential must be currently practicing an acceptable form of birth control, and have a negative urine pregnancy test Exclusion Criteria: * Patients with known allergy, hypersensitivity or contraindications to clonidine, gabapentin, anesthetic or analgesic medications * Patients with clinically-significant medical conditions, such as brain, heart, kidney, endocrine, or liver diseases, peptic ulcer disease or bleeding disorders * Patients with chronic hypertension or pain syndromes receiving clonidine or gabapentin, respectively. * Pregnant or lactating women * Subjects with a history of alcohol or drug abuse within the past 3 months * Patients taking any analgesic medications within 48 hours prior to the surgery * Any other conditions or use of any medication which may interfere with the conduct of the study * Non-English speakers * Patients greater than 80 years of age