Most children with cancer need a central venous catheter. These catheters are typically placed on the anterior thorax, where the risk of hypertrophic scarring and keloid development is greatly enhanced. A significant part of the children who have survived childhood cancer are troubled by their scars. Topical glucocorticoid treatment is known to induce a reduction of the collagen in the connective tissue. The investigators hypothesize that treatment with topical glucocorticoids for one week before and three weeks after removal of a central venous catheter, will reduce the formation of hypertrophic scarring and keloid development in children.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
60
0.4 cm creme is applied and covered with a plaster (treatment under occlusion). Dosage every second or third day Treatment is started one week before removal of the central venous catheter and continued for four weeks
0.4 cm creme is applied and covered with a plaster (treatment under occlusion). Dosage every second or third day Treatment is started one week before removal of the central venous catheter and continued for four weeks
Arhus University Hospital Skejby
Aarhus, Aarhus N, Denmark
scars measured by the Vancouver Scar Scale twelve months after central venous catheter removal
Time frame: Twelve months
Judgement of the scar by Patient and observer scar scale after six months
Time frame: six months
Judgement of the scar by Patient and observer scar scale after twelve months
Time frame: twelve months
scars measured by the Vancouver Scar Scale six months after central venous catheter removal
Time frame: six months
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