Study of the Metabolism of Two Magnesium Supplements in Healthy Volunteers

University of Aarhus10 enrolled

Overview

The present study is part of a project titled 'Magnesium in asthma and chronic obstructive pulmonary disease'. The hypothesis of the main project is that daily magnesium supplement will benefit patients with asthma and chronic obstructive pulmonary disease. The aim of this part of the project is to study the pharmacokinetics of the following two magnesium supplements: * Mablet (dietary supplement) * Magnesium Sulfate (solution for infusion)

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Masking

NONE

Enrollment

Conditions

Asthma Chronic Obstructive Pulmonary Disease

Interventions

Mablet (Magnesium-supplement)DIETARY_SUPPLEMENT

Mablet: Magnesium hydroxide/ -oxide (360 mg/tablet) 3 tablets as a single dose Produced by: Gunnar Kjems APS

Magnesium SulfateDRUG

Solution for a single bolus-infusion, containing 2 grams of magnesium sulfate.

Eligibility

Sex: MALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers. Exclusion Criteria: * Smokers, * Using pharmaceuticals/supplements, * Vegans/vegetarians, * Major changes in eating habits within one week prior to study start.

Locations (1)

Research Dept. of Respiratory Medicine, Aarhus University Hospital

Aarhus C, Denmark

Outcomes

Primary Outcomes

Pharmacokinetic parameters

Clearance, half-life \& absorption fraction

Time frame: Two years

Data from ClinicalTrials.gov

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