Omega-3 and Aspirin in Periodontal Regeneration

October 6 University40 enrolled

Overview

To evaluate the efficacy of systemic administration of omega 3 PUFA plus low dose aspirin as an adjunctive therapy to regenerative modality of grade II furcation defects in periodontitis patients.

In this study, we tested the hypothesis that the administration of omega 3 PUFA plus low dose aspirin would augment the results following regenerative therapy of furcation defects in chronic periodontitis patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Periodontal Disease

Interventions

Regenerative therapy (omega 3 PUFA plus low dose aspirin)OTHER

Comparison between regenerative bone graft alone and bone graft + Omega-3 and low dose aspirin

Sugar pillDRUG

3 times daily

Eligibility

Sex: ALLMin age: 35 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * suffering moderate to sever chronic periodontitis and displaying at least a single grade II furcation defect according to Glickman's classification 1953, determined by both clinical and radiographic examinations; * free from systemic diseases known to influence the periodontal condition and not receiving any medication known to affect the periodontal status; * have not receive any periodontal therapy for a minimum of 6 months prior to the study. Exclusion Criteria: * Known hypersensitivity or allergy to one of the used medications * Pregnancy or lactation * Heavy smoking (more than 10cigarretes/day) * History of alcohol abuse * Participation in other clinical trials

Locations (1)

October 6 University

Cairo, Overnorate of 6 October, Egypt

Outcomes

Primary Outcomes

Cytokine levels

Interleukin-1 beta Interleukin-10

Time frame: six months

Secondary Outcomes

Gingival inflammation

plaque index Gingival index Gingival bleeding index

Time frame: six months

Healing after regenerative therapy

Probing pocket depth Clinical attachment level

Time frame: six months

Data from ClinicalTrials.gov

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