Biomarkers for Prognosis of Ambulatory Chronic Heart Failure Patients

University of Parma124 enrolled

Overview

Biomarkers representing distinct biological domains including neurohormonal, inflammatory, metabolic-nutritional, oxidative-nitrosative and myocardial injury, might alone or in combination provide prognostic information on mortality in heart failure patients with preserved or impaired systolic function.

Upon enrollment in the study, Troponin I (cTn I), BNP, norepinephrine, plasma renin activity, aldosterone, high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), soluble receptor of interleukin 2 (sIL-2R), leptin, prealbumin, free malondialdehyde, 15-F2t-isoprostane and protein-bound nitrotyrosine were measured in stable ambulatory, non diabetic, elderly heart failure patients. Patients were followed up until death or study termination (31st January 2009).

Study Type

OBSERVATIONAL

Enrollment

124

Conditions

Heart Failure

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * symptomatic congestive heart failure lasting at least six months * reduced exercise tolerance * impaired or preserved left ventricular ejection fraction * cardiomegaly Exclusion Criteria: * acute infection * rheumatoid or other autoimmune diseases * primary cachectic states (cancer, thyroid disease, severe liver disease) * severe chronic lung disease * neuromuscular disorders * myocardial infarction within the previous 20 weeks * diabetes mellitus * chronic renal failure (serum creatinine level \> 2.0 mg/dl, \>177 micromol/L)

Locations (1)

Università di Parma

Parma, Italy

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.