Though cervical insufficiency is a common cause of second trimester pregnancy loss, the placement of an emergent cerclage in these patients is thought to improve perinatal outcomes. It is unknown whether the use of tocolytics and antibiotics prolongs pregnancies complicated by need for emergent cerclage. The objective is to determine whether administration of peri-operative antibiotics and indomethacin to patients receiving emergent cerclages for cervical insufficiency increases latency period to delivery compared with patients receiving emergent cerclage alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
53
q8hr dosing of po indomethacin 50mg X 24 hrs and q8 hr 1 g IV cefazolin or 600 mg IV clindamycin
Prentice Women's Hospital
Chicago, Illinois, United States
Gestational Latency Achieved Between Cerclage Placement and Time of Delivery
Median gestational latency achieved Between Cerclage Placement and Time of Delivery
Time frame: 24 weeks
Gestational Latency of More Than 28 Days
The frequency of achieving a gestational latency of more than 28 days
Time frame: 28 days postpartum
Gestational Age at Delivery
Median gestational age at delivery
Time frame: 24 weeks
Neonatal Morbidity and Mortality
Days spent in the neonatal intensive care unit
Time frame: 1 year
Birthweight
Median birthweight
Time frame: 24 weeks
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