The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy

University of Cologne62 enrolled

Overview

The aim of the study is to investigate whether it is possible to predict the success of trabeculectomy in patients with glaucoma through the examination of mediators of wound healing in anterior chamber fluid. The success rate of trabeculectomy with mitomycin C in the literature is about 75%. This leads on the question why 25% of the patients received trabeculectomy are not sufficient treated and have not a long-term IOP reduction. Precisely this question is to be examined by the study.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glaucoma Trabeculectomy Wound Healing

Interventions

TrabeculectomyPROCEDURE

Trabeculectomy with mitomycin C

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with glaucoma with a trabeculectomy required * 60 eyes of 60 patients, The ratio of female / male is not involved. * Eye pressure under local therapy: 20mmHg and above (corrected with pachymetry table). * age of at least 18 years Exclusion Criteria: * all patients not included in the group of inclusion criteria. * less than 50yl anterior chamber fluid could be collected during the operation.

Locations (1)

University Eye Hospital, University of Cologne

Cologne, North Rhine-Westphalia, Germany

Data from ClinicalTrials.gov

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