Efficacy of Allergen Immunotherapy for Allergic Rhinitis in Thais

Pongsakorn Tantilipikorn84 enrolled

Overview

The purpose of this study is to study the efficacy of allergen injection immunotherapy for allergic rhinitis by * symptoms score * medication score * quality of life * immunologic test from blood

Compare the efficacy of allergen injection immunotherapy between the treatment group and the placebo group after injection for * 2 months * 6 months * 12 months

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Rhinitis, Allergic, Perennial

Interventions

InterventionBIOLOGICAL

Dermatophagoides pteronyssinus from ALK company

ControlOTHER

Injection by buffer solution WITH standard allergic medication (oral antihistamine and/or topical nasal steroid)

Eligibility

Sex: ALLMin age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with the symptoms of allergic rhinitis who sensitized to mite (Dermatophagoides pteronyssinus) * positive skin prick test to D.p. at 4+ degree Exclusion Criteria: * steroid dependent asthma * force expiratory volume (FEV1) less than 70% of predicted value * previous injection immunotherapy within 2 years * pregnancy * medical conditions such as ischemic heart disease, autoimmune disease, cancer, previous history of anaphylaxis

Locations (1)

Division of Allergy and Rhinology, Faculty of Medicine Siriraj, Mahidol University

Bangkok, Thailand

Outcomes

Primary Outcomes

Total nasal symptoms score

3 point scale (0,1,2,3) and combination of * nasal block * rhinorrhea * itching * sneezing

Time frame: average within 1 week

Secondary Outcomes

Combined total symptoms score and medication score

Total symptom score (nasal block, rhinorrhea, itching, sneezing, and eye symptoms with chest symptoms = Maximal score --\> 18 devided by 6 = 3) PLUS medication score ( antihistamine = 1, topical nasal steroid = 2; --\> Maximal score = 3).

Time frame: average within 1 week

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.