Effects of Pioglitazone on Insulin Sensitivity in Healthy Overweight and Obese Males (MK-0000-170)

Inclusion Criteria: * Subject has a BMI of greater than 28 kg/m\^2 and less than or equal to 38 kg/m\^2 * Subject has been a nonsmoker and/or has not used nicotine or nicotine-containing products for at least approximately 6 months * Subject is willing to avoid major dietary changes for the duration of the study Exclusion Criteria: * Subject has history of diabetes (Type 1, Type 2 or steroid-induced) * Subject has a history of hypersensitivity to pioglitazone or other thiazolidinediones * Subject has a history of liver disease, other than non-alcoholic fatty liver disease or non-alcoholic steatohepatitis * Subject has a history of congestive heart failure * Subject has a active or past history of atherosclerotic heart disease, heart failure, osteoporosis, osteopenia, recurrent bone fractures, or anemia * Subject has a history of stroke, chronic seizures, or major neurological disorder * Subject has a history of clinically significant endocrine, gastrointestinal, cardiovascular, hematological or renal abnormalities or diseases * Subject has a history of neoplastic disease within the past 5 years