Pharmacokinetic Study of Bramitob® Administered for Inhalation by PARI eFlow® vs PARI LC® PLUS Nebulizer

Main inclusion Criteria: * Patients of either sex aged ≥ 18 years; * Clinical diagnosis of cystic fibrosis (patients registered in the National Registry of cystic fibrosis or other documents, if applicable, depending on country legislation); * Positive response (sweat chloride concentration ≥ 60 mmol/l) in the standard sweat test documented in the clinical records or sweat chloride concentration ≥ 40 mmol/l and at least two gene mutations consistent with CF documented in the clinical records; * Chronic colonization of Pseudomonas aeruginosa * FEV1 ≥ 35% of the predicted normal value calculated according to the recommendation of the Official Statement of the European Respiratory Society and American Thoracic Society Main exclusion Criteria: * Evidence of impaired renal function (serum creatinine level ≥ 1.5 mg/dl); * Evidence of impaired auditory function (auditory threshold in either ear above 20 dB at frequencies between 250 and 8000Hz); * Sputum culture containing Burkholderia cepacia; * Received loop diuretics within 7 days before study drug administration;