Impact of Hot Flashes on Sleep and Mood Disturbance

Inclusion Criteria: * Women 18-45 years old * Premenopausal * Willingness to use barrier methods of contraception during study and after completion of study until menses resume * Good general health Exclusion Criteria: * Pregnancy or currently breastfeeding * Hot flushes * Mid-luteal phase progesterone \<3ng/mL * Clinically significant abnormalities in screening blood tests * BMI \> 35 kg/m2 * Previously diagnosed osteoporosis or osteopenia * Clinically significant depressive symptoms * Psychiatric illness * Sleep apnea or periodic limb movement of sleep (PLMS) * Contraindication, hypersensitivity, or previous allergic reaction to GnRH agonists * Current or recent use of centrally active medications * Current or recent use of systemic hormone medications * Night shift workers * Current use of over-the-counter (OTC) medications that may affect hot flashes, sleep, or mood * Abnormal vaginal bleeding * History of any medical diseases that may put subject at risk when treated with study medication.