Study of the Inflammatory Reaction in Standard vs Single Port Cholecystectomy for Uncomplicated Cholelithiasis

G. Hatzikosta General Hospital40 enrolled

Overview

This is a study of the inflammatory reaction in standard 4 port laparoscopic cholecystectomy vs Single Port Laparoscopic (SIL) cholecystectomy. It is assumed that the reduced trauma in SIL Cholecystectomy causes reduced inflammatory reaction compared to the 4 port laparoscopic cholecystectomy.

Two groups of 20 patients each are included in this study. Pre operatively, 6 and 24 hours postoperatively, blood is taken from these patients, it is centrifuged and the plasma is taken. IL-6, a-defensins and CRP are measured for each sample.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Cholelithiasis Inflammatory Response

Interventions

Single incision laparoscopic cholecystectomyOTHER

One port placed through the umbilicus

Laparoscopic cholecystectomyOTHER

Standard 4 port laparoscopic cholecystectomy

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Uncomplicated cholelithiasis * American Society of Anesthesiologists (ASA) I or II * No previous operations in upper abdomen * Body mass index (BMI) \<30 Exclusion Criteria: * Cholecystitis * ASA \> II * BMI\>30 * Previous operations in upper abdomen * Previous operations in intestine

Locations (1)

"G. Hatzikosta" General Hospital of Ioannina

Ioannina, Greece

Data from ClinicalTrials.gov

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