Safe Drinking Water For Households With Infants Born to HIV-Positive Mothers Pilot Study

London School of Hygiene and Tropical Medicine120 enrolled

Overview

The purpose of this study is to assess whether children under 2 years and other members of households in which HIV-positive mothers are providing replacement and complementary feeding would potentially benefit from the use of a filter designed to eliminate microbial pathogens from drinking water at the household level.

Contaminated drinking water is a leading cause of morbidity and mortality in low-income settings. Safe drinking water is of particular concern for HIV-positive mothers since many HIV-infected Zambian women choose replacement feeding and early cessation of breastfeeding of infants to minimize the risk of transmission of the virus. This study builds upon preliminary baseline research which determined that HIV-positive mothers would potentially benefit from an intervention that encourages HIV-positive mothers to treat their water at the household level.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

120

Conditions

Diarrhea HIV Infection

Interventions

LifeStraw FamilyDEVICE

LifeStraw Family is a household water treatment technology that will be implemented in the household to improve drinking water quality

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Known HIV-status based on clinical testing * Have a child between 6-12 months at the initiation of the study * Within the catchment area of Kasisi or Ngwerere health clinics, Chongwe district, Lusaka Exclusion Criteria: * Lived in the catchment area less than one year or planning to move

Locations (1)

Ngwerere Health Clinic and Kasisi Health Clinic

Lusaka, Chongwe District, Lusaka Province, Zambia

Outcomes

Primary Outcomes

Use of LifeStraw Family for children under 2 and all household members

Use, acceptability, and longevity of LifeStraw Family will be assessed for replacement and complementary feeds for children under 2 and for drinking water for all members of the household

Time frame: One year

Secondary Outcomes

Microbiological performance of LifeStraw Family

Microbiological performance of LifeStraw Family, measured in terms of thermotolerant coliforms (TTC), a well-established WHO indicator organism for faecal contamination

Time frame: One year

Impact of LifeStraw Family on longitudinal prevalence of diarrhea

Impact of the intervention on longitudinal prevalence of diarrhoea among infants under 2 years and all household members, measured both as reported by the primary caretaker of the child and by their weight-for-age z-score (WAZ) as a proxy for diarrhoea

Time frame: One year

Data from ClinicalTrials.gov

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