Rollover Study of VX-770 in Cystic Fibrosis Subjects

Inclusion Criteria: 1. Participants who have completed the assigned study treatment in Study 102 or Study 103 2. Participants who are females of childbearing potential must have a negative urine pregnancy test on Day 1 (first dose of VX-770) 3. Participants who are able to understand and comply with protocol requirements, restrictions, and instructions and likely to complete the study as planned, as judged by the investigator 4. Participants of child bearing potential and who are sexually active must meet the contraception requirements 5. Participants must sign the informed consent form (ICF), and where appropriate, assent must be obtained Exclusion Criteria: 1. Participants with a history of any illness or condition that, in the opinion of the investigator, might confound the results of the study or pose an additional risk in administering study drug to the subject 2. Participants with a history of study treatment intolerance as observed in their previous VX-770 study that, in the opinion of the investigator, might pose an additional risk in administering study drug to the subject 3. Participants who are pregnant, planning a pregnancy, breast-feeding, or not willing to follow contraception requirements 4. Participants taking any inhibitors or inducers of Cytochrome P450 3A4 (CYP3A4), including certain herbal medications (for example, St. John's Wort) and grapefruit/grapefruit juice