This is a multiple vaccination study to find out if it is a safe treatment and what effects it has on the symptoms of early Alzheimer's disease in male and female patients aged 50 to 80 years. Approximately 40 study sites in Europe will be involved. Patients will be randomized to receive either AFFITOPE AD02 or placebo. Each patient's participation will last 1 year.
AFFITOPE AD02 is a second generation AD immunotherapeutics targeting Aβ. Its active component is a synthetic peptide functionally mimicking the unmodified N-terminus of Aβ.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
335
vaccination
vaccination
cognitive(ADAS-cog modified) and functional(ADCS-ADL modified)
Time frame: 18 months
cognitive(computerised test battery), global(CDR-sb), behavioral(NPI), biomarker (volumetric MRI)
Time frame: 18 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Landeskrankenhaus Hall Gedächtnisambulanz
Hall in Tirol, Austria
LNK Wagner-Jauregg, Dept. of geriatrics
Linz, Austria
Christian Doppler Klinik, Univ. Klinik f. Neurologie
Salzburg, Austria
Studienzentrum der PROSENEX, Ambulatoriumbetriebsges.m.b.H an der Confraternität - Privatklinik Josefstadt
Vienna, Austria
MUW Klin. Pharmakologie und Klinik für Neurologie
Vienna, Austria
MUW, Klin.Abt.f. Biolog. Psychiatrie
Vienna, Austria
SMZ-Ost, Psychiatric Dep.
Vienna, Austria
Klinčki Bolnički Centar Rijeka, Klinika za Psihijatriju
Rijeka, Croatia
Opća bolnica Varaždin, Klinika za Neurologiju
Varaždin, Croatia
"BONIFARM" Poliklinika za kliničku farmakologiju i toksikologiju
Zagreb, Croatia
...and 21 more locations