Vasodilator Free Measure of Fractional Flow Reserve

Imperial College London157 enrolled

Overview

Narrowing of coronary arteries interferes with blood flow and can cause chest pain. Cardiologists sometimes quantify the extent of the narrowing by measuring the fractional flow reserve (the ratio of the pressure in the aorta to the pressure downstream of the narrowing under conditions of maximal flow). We propose a new technique based on principles of wave intensity analysis (WIA) to better assess coronary stenosis and the significance of the narrowing without the need for administration of vasodilator agents such as adenosine. This would simplify assessment and improve our ability to advise patients whether stent treatment will help their symptoms.

Study Type

OBSERVATIONAL

Enrollment

157

Conditions

Coronary Stenosis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with coronary stenosis Exclusion Criteria: * Patient's with cardiac pacemakers, valvular heart disease, and chronic renal failure * Unable to consent * Contraindications to adenosine * Contraindications to cardiac MRI

Locations (1)

Imperial College NHS Trust

London, United Kingdom

Outcomes

Primary Outcomes

Correlation and descriptive characteristics between adenosine free measure of stenosis severity and FFR

Time frame: Study end

Data from ClinicalTrials.gov

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