Aurora B/C Kinase Inhibitor GSK1070916A in Treating Patients With Advanced Solid Tumors

Eligibility criteria The patient must fulfil the eligibility criteria (listed in Section 4.1.1 and 4.1.2). Additional eligibility criteria must be fulfilled for the expanded MTD cohort (listed in Section 4.1.3). 4.1.1 Inclusion criteria: 1. Histologically or cytologically proven solid tumour refractory to conventional treatment, or for which no conventional therapy exists 2. Life expectancy of at least 3 months 3. World Health Organisation (WHO) performance status of 0 or 1 4. Haematological and biochemical indices within the ranges shown below. These measurements must be performed within one week (Day -7 to Day -1) before the patient goes on study. Laboratory Test Value required Haemoglobin (Hb) ≥ 10.0 g/dL Absolute neutrophil count (ANC) ≥ 1.5 x 109/L Platelet count ≥ 100 x 109/L Serum bilirubin ≤ 1.5 x upper limit of normal (ULN) Alanine aminotransferase (ALT) AND aspartate aminotransferase (AST) ≤ 2.5 x ULN unless raised due to tumour in which case up to 5 x ULN is permissible Calculated creatinine clearance (preferably measured by EDTA/ DTPA (isotope method) otherwise to be calculated using Wright formula) ≥ 50 mL/min (uncorrected value) 5. 18 years or over 6. Written (signed and dated) informed consent and be capable of co-operating with treatment and follow-up 4.1.2 Exclusion criteria: 1. Radiotherapy (except for palliative reasons), endocrine therapy, immunotherapy or chemotherapy during the previous four weeks (six weeks for nitrosoureas, Mitomycin-C and six weeks for investigational medicinal products) before treatment. 2. Ongoing toxic manifestations of previous treatments. Exceptions to this are alopecia or certain Grade 1 toxicities, which in the opinion of the Investigator and the Drug Development Office (DDO) should not exclude the patient. 3. Known brain metastases. 4. Patients on therapeutic anti-coagulation with warfarin are excluded. (1mg warfarin for line maintenance is acceptable; conversion to low molecular weight heparin is acceptable but must be done a minimum of seven days prior to the first dose of study drug). 5. Ability to become pregnant (or already pregnant or lactating). However, those female patients who have a negative serum or urine pregnancy test before enrolment and agree to use two highly effective forms of contraception (oral, injected or implanted hormonal contraception and condom, have a intra-uterine device and condom, diaphragm with spermicidal gel and condom) for four weeks before entering the trial, during the trial and for six months afterwards are considered eligible. 6. Male patients with partners of child-bearing potential (unless they agree to take measures not to father children by using one form of highly effective contraception \[condom plus spermicide\] during the trial and for six months afterwards). Men with pregnant or lactating partners should be advised to use barrier method contraception (e.g. condom plus spermicidal gel) to prevent exposure to the foetus or neonate. 7. Major thoracic or abdominal surgery from which the patient has not yet recovered. 8. At high medical risk because of non-malignant systemic disease including active uncontrolled infection. 9. Known to be serologically positive for hepatitis B, hepatitis C or human immunodeficiency virus (HIV). 10. QTc interval ≥ 450 msecs for men and ≥ 470 msecs for women or other clinically significant electrocardiogram (ECG) abnormalities (QTc preferably calculated using the algorithm in Appendix 6). 11. Use of medicines known to prolong QTc within 14 days prior to the first dose of study drug (see Category 1 of Appendix 5). 12. Previous exposure to aurora kinase inhibitors 13. Concurrent congestive heart failure, prior history of class III/ IV cardiac disease (New York Heart Association \[NYHA\] - refer to Appendix 4) 14. History of cardiac ischaemia, cardiac arrhythmias, coronary angioplasty or stenting in the previous 12 months. Patients currently on medication for cardiac arrhythmias are also excluded. 15. Patients with a known left ventricular ejection fraction (LVEF) \<50%. A multi-gated acquisition (MUGA) scan or echocardiogram must be performed if clinically indicated. 16. Any other condition which in the Investigator"s opinion would not make the patient a good candidate for the clinical trial. 17. Is a participant or plans to participate in another interventional clinical study, whilst taking part in this Phase I study of GSK1070916A. Participation in an observational study would be acceptable. 4.1.3 Additional inclusion / exclusion criteria for expanded MTD cohort: Once tolerability has been confirmed in the initial three to six patients of the MTD, further patients in this expanded cohort must either consent to have tumour biopsies taken or having FDG PET-CT and DW/DCE-MRI scans performed. The minimum number of patients required in each part of the expansion cohort is six. The following additional inclusion / exclusion criteria will apply. For patients consenting to tumour biopsies: 1. Additional written (signed and dated) informed consent for tumour biopsies must be given. 2. The patient"s tumour should be amenable to biopsy. For patients consenting to FDG PET-CT and DW/DCE-MRI scans: 3. Additional written (signed and dated) informed consent for FDG PET-CT and DW/DCE-MRI scans must be given. 4. Patients with diabetes must have their condition under good control (blood sugar less than 10mmol/L). 5. Patients must be able to tolerate / comply with imaging protocol (i.e. patients with high levels of pain, urinary incontinence, or claustrophobia etc should be excluded). 6. Patients with tumours known to be poorly FDG avid (e.g. mucinous adenocarcinoma, well differentiated neuroendocrine or hepatocellular carcinoma) or falsely negative (e.g. all tumours less than 5-6mm) are excluded. Refer to Appendix 7 for full list of excluded tumours. 7. Patients with implanted metallic devices (e.g. pacemaker) are excluded.