Fluoxetine Versus Fluoxetine Plus DU125530 in Major Depressive Disorder

Inclusion Criteria: * Consecutive eligible patients aged 18 to 70 * Diagnosis of unipolar major depression using DSM-IV criteria with moderate to severe symptoms (score e 18 on the Hamilton Depression Rating Scale-HDRS- of 17 items). * There was a wash-out of 1 week of any antidepressant drug (specifically 28 days for fluoxetine) prior entering the study. * Written informed consent was obtained from all participants. Exclusion Criteria: * Concurrent psychiatric disorders (DSM IV axis I, II cluster A or B) * Failure to respond to drug treatment in current depressive episode * Previous resistance to SSRIs or other antidepressant drug * Suicide risk score e 3 on the HDRS. * Participation in other drug trials within the previous month * Presence of delusions or hallucinations * History of substance abuse (including alcohol) in the past three months * Pregnancy or lactation * Organic brain disease or history of seizures * Serious organic illnesses such as hypo or hyperthyroidism,cardiac arrhythmias, asthma, diabetes mellitus. * Myocardial infarction in the past 6 month * Frequent or severe allergic reactions * Concomitant use of other psychotropic drugs (benzodiazepines were allowed), lockers or catecholamine-depleting agents * Current structured psychotherapy.