Biomarkers in Tissue Samples From Patients With Stage I or Stage III Endometrial Cancer

N/AUnknownNCT01119573

Gynecologic Oncology Group100 enrolled

Overview

RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying at biomarkers in tissue samples from patients with stage I or stage III endometrial cancer.

OBJECTIVES: * To identify microRNA expression patterns associated with lymph node metastasis in samples from patients with endometrial cancer. OUTLINE: Banked tumor tissue specimens are analyzed for microRNA expression profiling by microarray analysis and reverse transcriptase-PCR assays.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Endometrial Cancer

Interventions

RNA analysisGENETIC

microarray analysisGENETIC

reverse transcriptase-polymerase chain reactionGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Histologically confirmed endometrioid endometrial cancer * Stage IA, IB, IC, or IIIC disease * Any grade * Enrolled and evaluated on GOG-0210 Molecular Staging Study of Endometrial Cancer * Consented to allow their specimens and clinical data to be collected and stored for future research * Underwent complete surgical staging, including the following: * Hysterectomy * Bilateral oophorectomy * Washings as well as pelvic lymphadenectomy (sampling of four left and four right pelvic lymph nodes) * Para-aortic lymphadenectomy (sampling of one left and one right para-aortic lymph node) * Sufficient high-quality frozen primary tumor for testing with ≥ 75% tumor cellularity and ≤ 10% necrosis PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * See Disease Characteristics

Outcomes

Primary Outcomes

Association between microRNA expression and lymph node metastasis

Data from ClinicalTrials.gov

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