In this study, the effects of dietary intake of cold-pressed turnip rapeseed oil (CTPRO) and milk fat are compared in men with metabolic syndrome having already participated in HMS-02 study.
This open and balanced cross-over study consists of two dietary treatment phases (either Virgino (R) CTPRO or butter) for 6 to 8 weeks. They are separated from each other with an eight-week washout period. At the end of both periods and 12-hour fasting an oral glucose-fat tolerance test is carried out. Except glucose, the test consists cream (after the butter phase) and CTPRO (after the CTPRO phase). Otherwise, the subjects (n=43) are asked to maintain their normal dietary habits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
43
1. In the dietary period of 6 to 8 weeks: CTPRO 37 ml/day. 2. In the 5-hour oral glucose and fat tolerance test: glucose and CTPRO.
1. In dietary period of 6 to 8 weeks: 37.5 grams of butter. 2. In the 5-hour oral glucose and fat tolerance test: glucose and cream
Linnan Klinikka
Hämeenlinna, Finland
Central Hospital of Kanta-Häme
Hämeenlinna, Finland
Finnish Red Cross Blood Transfusion Service
Helsinki, Finland
MTT Agrifood Research Finland
Jokioinen, Finland
Circulating lipids
At the end of both 6- to 8-week dietary periods, fasting values of circulating lipids including oxidized LDL are determined
Time frame: 6 to 8 weeks
Platelet function
At the end of both 6- to 8-week dietary periods, platelet function is determined
Time frame: 6 to 8 weeks
Glucose tolerance
During a 5-hour oral glucose-fat tolerance test the area under curve of plasma glucose and insulin concentration is determined
Time frame: 5 hours
Arterial elasticity
At the end of both 6- to 8-week dietary periods, arterial elasticity is determined
Time frame: 6 to 8 weeks
Serum triglyceride AUC
During a 5-hour oral glucose-fat tolerance test the area under curve of serum triglyceride concentration is determined
Time frame: 5 hours
Platelet function
During a 5-hour oral glucose-fat tolerance test the platelet function is determined
Time frame: 5 hours
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