S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery

DISEASE CHARACTERISTICS: * Histologically or cytologically confirmed renal cell carcinoma * Clear cell or non-clear cell allowed * No disease of the collecting duct or medullary carcinoma * Considered pathologically either intermediate high-risk or very high-risk disease * No history of distant metastases * Patients with microvascular invasion of the renal vein of any grade or stage (as long as M0) are eligible * Have undergone a full surgical resection (radical nephrectomy or partial nephrectomy) including removal of all clinically positive nodes * Surgical margins must be negative * Patients with positive renal vein margins are eligible unless there is invasion of the renal vein wall at the margin (provided no other margins are positive) * Patients must be registered within 84 days after the date of the first surgical resection of the first tumor * No evidence of residual or metastatic renal cell cancer on CT scan of the chest, abdomen, and pelvis (all with oral and IV contrast) performed after nephrectomy and within 28 days before registration * MRI scans of the abdomen and pelvis with gadolinium and a non-contrast CT scan of the chest may be substituted if the patient is not able to have CT scans with IV contrast PATIENT CHARACTERISTICS: * Zubrod performance status 0-1 * ANC ≥ 1,500/mm\^3 * Platelet count ≥ 100,000/mm\^3 * Serum creatinine ≤ 2.0 times upper limit of normal (ULN) OR calculated creatinine clearance ≥ 30 mL/min * Bilirubin ≤ 1.5 times ULN * SGOT and SGPT ≤ 2.5 times ULN * Not pregnant or nursing * Fertile patients must use effective contraception during and for up to 8 weeks after completion of study treatment * Able to take oral medications * Patients must not have any of the following: * NYHA class III-IV cardiac disease (i.e., patients with cardiac disease resulting in marked limitation of physical activity or resulting in inability to carry on any physical activity without discomfort) * Unstable angina pectoris * Myocardial infarction within the past 6 months * Serious uncontrolled cardiac arrhythmia * Patients must NOT have liver disease such as cirrhosis or severe hepatic impairment (Child-Pugh Class C) * HBV and HCV testing are required at screening for all patients with a positive medical history based on risk factors and/or confirmation of prior HBV/HCV infection * Must be able to take oral medications * No impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of everolimus (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, or small bowel resection) * No known history of HIV seropositivity * No known uncontrolled, underlying pulmonary disease (spirometry and DLCO ≤ 50% of predicted OR oxygen saturation ≤ 88% at rest on room air) * No uncontrolled hyperlipidemia (fasting serum cholesterol \> 300 mg/dL AND fasting triglycerides \> 2.5 times ULN) obtained within 28 days prior to registration * Optimal lipid control must be achieved before registration and monitored during protocol treatment * No uncontrolled diabetes mellitus (defined by fasting serum glucose \> 1.5 times ULN) obtained within 28 days prior to registration. * Optimal glucose control must be achieved before registration and monitored during protocol treatment * No prior malignancies except for any of the following: * Adequately treated basal cell or squamous cell skin cancer * In situ cervical cancer * Adequately treated stage I or stage II cancer from which the patient is currently in complete remission * Any other cancer from which the patient has been disease-free for 5 years * No known hypersensitivity to everolimus or other rapamycins (sirolimus, temsirolimus) or to their excipients * No contraindications to receiving either IV iodine-based contrast or gadolinium PRIOR CONCURRENT THERAPY: * See Disease Characteristics * Patients must have recovered from any surgery-related complications * No prior anticancer therapy for renal cell carcinoma including systemic therapy in the adjuvant or neoadjuvant setting, immunotherapy, investigational therapy, surgical metastasectomy, or radiotherapy * More than 14 days since prior and no concurrent strong CYP3A4 inhibitors (i.e., ketoconazole, itraconazole, voriconazole, posaconazole, fluvoxamine, nefazodone, nelfinavir, or ritonavir) or strong CYP3A4 inducers (i.e., phenytoin, rifampin, or rifabutin) * More than 7 days since prior and no concurrent live vaccines * No other concurrent anticancer agents including investigational agents * No concurrent chronic treatment with systemic steroids or another immunosuppressive agent * Topical or inhaled corticosteroids are allowed