Pharmacokinetic, Pharmacodynamic and Tolerability Study of Otamixaban in Patients With Mild, Moderate and Severe Renal Impairment

Inclusion criteria: * Subject with renal impairment: * Mild, moderate or severe renal impairment defined as Creatinine Clearance (CrCl) from 50 to 80, 30 to 50 and \< 30 mL/min respectively, based on the Cockcroft-Gault formula, * Body weight between 50.0 kg and 115.0 kg inclusive if male, between 40.0 kg and 95.0 kg inclusive if female, Body Mass Index between 18.0 and 34.9 kg/m2 inclusive. * Stable chronic renal impairment as defined by Cockcroft-Gault formula, * Vital signs, cardiac function and laboratory parameters within the acceptable range. * Or matched subject (by age, gender and body weight) with normal renal function (defined as CrCl \>80 mL/min) and certified as healthy by physical examination, medical history and laboratory findings. * If female, subject must use a double contraception method, except if she is sterilized for more than 3 months or postmenopausal. Exclusion criteria: * Uncontrolled clinically relevant cardiovascular, pulmonary, gastro-intestinal, metabolic, hematological, neurological, psychiatric, systemic, ocular, gynecologic (if female) or infectious disease, or signs of acute illness. * Active hepatitis, hepatic insufficiency. * Acute renal failure, nephrotic syndrome. * History of or current hematuria of urologic origin. * Subject requiring dialysis during the study. * History or presence of drug or alcohol abuse within two years before inclusion. * Smoking more than 15 cigarettes or equivalent per day. * Any significant change in chronic treatment medication within 14-days before inclusion. The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.