Effects of Fructose and Exercise on Hepatic Lipid Metabolism

University of Lausanne8 enrolled

Overview

8 healthy male volunteers will be studied each on 3 occasions, ie * after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity * after 4 days on a weight maintenance diet containing 30% fructose + low physical activity * after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Metabolism

Interventions

weight maintenance, low sugar dietBEHAVIORAL

weight maintenance, high fructose dietBEHAVIORAL

weight maintenance, high fructose diet+ exerciseBEHAVIORAL

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age between 18 and 30 years * males * BMI between 19 and 25 * low to moderate physical activity (\< 3 sessions/week) Exclusion Criteria: * smoking * consumption of alcohol\>50g/week * consumption of drugs or illicit substances * food allergies

Locations (1)

Centre Hospitalier Universitaire Vaudois

Lausanne, Canton of Vaud, Switzerland

Outcomes

Primary Outcomes

Hepatic de novo lipogenesis

Measurement of 13C VLDL palmitate after ingestion of 13C fructose

Time frame: after 4 days on controlled diet+exercise

Secondary Outcomes

Plasma VLDL-triglyceride kinetics

Modelling of 2H5-glycerol incorporation in VLDL afetr administration of a bolus of 2H5 glycerol

Time frame: after 4 days on controlled diet+exercise

Data from ClinicalTrials.gov

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