This study is to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of ASP1941 in healthy adult male subjects.
This study consists of two parts. In part-1, a single oral dose of ASP1941 or placebo is administered to healthy adult male subjects to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics in healthy adult males. In part-2, ASP1941 or placebo are is administered by a multiple dose regimen.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
SINGLE
Enrollment
84
Unnamed facility
Kantou, Japan
Safety assessed by adverse events, vital signs, 12-lead ECG and lab-tests
Time frame: 72 hours after drug administration
Plasma concentration of unchanged drug measured by blood sample
Time frame: 72 hours after drug administration
Blood glucose level measured by blood sample
Time frame: 72 hours after drug administration
Urinary glucose excretion level
Time frame: 72 hours after drug administration
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