A Study to Compare the Bioavailability of 300 mg Trazodone Hydrochloride Extended-release Caplets and 100 mg Trazodone Hydrochloride Immediate-release Tablets (Administered Three Times Daily)

Inclusion Criteria: * Healthy male and female subjects 18 to \< 56 years of age. * Body mass within 10% of the ideal mass in relation to height and age, according to Body Mass Index. * Body mass not less than 53 kg. * Findings within the range of clinical acceptability in medical history and physical examination, and laboratory results within the laboratory reference ranges for the relevant laboratory tests (unless the investigator considered the deviation to be irrelevant for the purpose of the study). * Normal 12-lead electrocardiogram (ECG) and vital signs, or abnormalities, which the investigator did not consider a disqualification for participation in the study. * Willingness to undergo a pre- and post-study physical examination and laboratory investigations. * Ability to comprehend and willingness to sign both statements of informed consent (for screening and period-related procedures). * Non-smoker or past smoker who stopped the use of any form of tobacco, including snuff or similar products, at least 3 months before entering the study. * For females, the following conditions had to be met: 1. Had been surgically sterilized or undergone a hysterectomy, or 2. Was of childbearing potential, and all of the following conditions were met: 1. Had a negative pregnancy test at screening. If this test was positive, the subject was to be excluded from the study before receiving study medication. In the rare circumstance that a pregnancy was discovered after the subjects received the study medication, every attempt was to be made to follow such subjects to term. 2. Had to agree to use an accepted method of contraception (i.e., spermicide and barrier methods or spermicide and non-hormonal intrauterine contraceptive device). The subject had to agree to continue with the same method throughout the study. Hormonal contraceptives were not allowed. 3. Females not of childbearing potential could also have been included if they had no menstrual period for one year and were considered as post-menopausal. Exclusion Criteria: * Evidence of psychiatric disorder, antagonistic personality, poor motivation, emotional or intellectual problems likely to have limited the validity of consent to participate in the study or to have limited the ability to comply with protocol requirements. * History of, or current compulsive alcohol abuse (\> 10 drinks weekly), or regular exposure to other substances of abuse. * Use of any medication, prescribed or over-the-counter, within 2 weeks prior to the first administration of study medication except if this would not have affected the outcome of the study in the opinion of the investigator. Hormonal contraceptive agents were not allowed. * Participation in another study with an experimental drug, where the last administration (of previous study medication) was within 8 weeks before the first administration of study medication. * Treatment within the previous 3 months with any drug with a well-defined potential for adversely affecting a major organ or system. * A major illness during the 3 months before commencement of the screening period. * History of hypersensitivity to the study medication or any related medication. * History of bronchial asthma. * History of epilepsy. * History of porphyria. * Relevant history or laboratory or clinical findings indicative of acute or chronic disease, likely to have influenced the study outcome. * Donation or loss of blood equal to or exceeding 500 mL during the 8 weeks before the first administration of study medication. * Diagnosis of hypotension made during the screening period. * Diagnosis of hypertension made during the screening period or current diagnosis of hypertension. * Resting pulse of \> 100 beats per minute or \< 40 beats per minute during the screening period, either supine or standing. * Positive testing for HIV and/or Hepatitis B and/or Hepatitis C. * Positive urine screen for drugs of abuse. * Positive urine screen for tobacco use. * A serum pregnancy test (beta human chorionic gonadotropin \[β-HCG\]) either positive or not performed or lactation.