The purpose of this study is to evaluate the safety and efficacy of fixed combination of lercanidipine (10 mg or 20 mg) and valsartan (80 mg or 160 mg), lercanidipine and valsartan alone in reducing blood pressure. The study will investigate the dose response relationship for the combinations and monotherapies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
441
L10/V80, L20/V80, L10/V160, L20/V160
L10, L20, V80, V160
Placebo of Lercanidipine and Valsartan
Seoul National University Hospital
Seoul, South Korea
23 sites in Korea
Seoul, Busan Etc., South Korea
sitDBP
Average changes from baseline in sitDBP
Time frame: Baseline, Week 8
sitDBP
Response rates (proportion of patients sitDBP\<90mmHg or ≥10-mmHg reduction from baseline)
Time frame: Week 4, 8
sitDBP
Average changes from baselin in sitDBP
Time frame: Week 4
sitSBP
Average changes from baselini in sitSBP
Time frame: Week 4, 8
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