This study will examine the brain metabolic effects of AC-1202 (Axona®), a medical food for Alzheimer's disease. Subjects who meet entry criteria will undergo H215O positron emission tomography prior to and 90 minutes after consumption of Axona® at baseline and then again after 45 days of treatment. Cognitive testing will also be conducted at baseline and day 45.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
17
Axona® is dosed as a 40g packet mixed into 8 oz of liquid (Ensure) for 45 days
200 Medical Plaza, UCLA Medical Center
Los Angeles, California, United States
Center for Neurotherapeutics at UCLA
Los Angeles, California, United States
Regional cerebral blood flow (rCBF)
Time frame: At baseline
Regional cerebral blood flow (rCBF)
Time frame: 90 minutes after initation of treatment with Axona®
Regional cerebral blood flow (rCBF)
Time frame: 45 days after initation of treatment with Axona®
Examine differences between ApoE ε4 carriers and noncarriers in changes on rCBF and cognition
Time frame: At baseline
To examine the effect of AC-1202 on cognition
Time frame: At baseline
Examine differences between ApoE ε4 carriers and noncarriers in changes on rCBF and cognition
Time frame: At 90 minutes after initiation of treatment with Axona®
Examine differences between ApoE ε4 carriers and noncarriers in changes on rCBF and cognition
Time frame: 45 days after initiation of treatment with Axona®
To examine the effect of AC-1202 on cognition
Time frame: At 90 minutes after initiation of treatment with Axona®
To examine the effect of AC-1202 on cognition
Time frame: 45 days after initiation of treatment with Axona®
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