Pharmacokinetics of Anacetrapib (MK0859) in Subjects With Impaired Renal Function (MK-0859-038)

Merck Sharp & Dohme LLC24 enrolled

Overview

This study will evaluate the Area Under the Curve (AUC(0 to infinity)) of anacetrapib in subjects with impaired renal function and healthy matched control subjects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Dyslipidemia

Interventions

anacetrapibDRUG

single dose administration of anacetrapib (MK0859) 100 mg oral tablet

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female subjects of reproductive potential test negative for pregnancy and agree to use two acceptable methods of birth control throughout the study * Subject is in good health * If Subject is a smoker, smoking is limited to no more than 10 cigarettes per day Exclusion Criteria: * Subject has a history of stroke, chronic seizures or major neurological disorder * Subject has a history of cancer * Subject is unable to refrain from or anticipates the use of any prescription or non-prescription medication during the study * Subject consumes excessive amounts of alcohol or caffeine * Subject has had major surgery, donated blood or participated in another investigational study within the past 4 weeks * Subject is a nursing mother * Subject has had a kidney removed or has a functioning renal transplant

Outcomes

Primary Outcomes

Area Under the Curve (AUC(0 to infinity)) of anacetrapib

Time frame: through 168 hours post dose

Secondary Outcomes

Safety and tolerability of a single dose administration of 100mg anacetrapib, measured by the number of clinical and laboratory adverse events

Time frame: through 14 days post dose

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.