Influence of Adiponutrin in Chronic Liver Disease

Erasme University Hospital658 enrolled

Overview

Increasing evidence attests the influence of multiple metabolic genetic risk factors in the progression of alcoholic liver disease. Deleterious pathways involved in metabolism such as lipid peroxidation and cytokines have been implicated in promoting inflammation leading to fibrosis increase and liver injury progression. The aim of this study was to assess the role of rs738409 single nucleotide polymorphism in the PNPLA3 gene in alcoholic liver disease patients.

Study Type

OBSERVATIONAL

Enrollment

658

Conditions

Alcoholic Liver Disease

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

ALD patients: Inclusion Criteria: * Excess alcohol intake * Abnormal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) or a suspicion of cirrhosis related to ALD * Caucasian ethnicity Exclusion Criteria: * Presence of any other chronic liver disease * Co-infection with human immunodeficiency virus Controls: Inclusion Criteria: * Caucasian ethnicity Exclusion Criteria: * Presence of a disease

Locations (1)

Hopital Erasme- Dpt of Gastroenterology

Brussels, Belgium

Outcomes

Primary Outcomes

Assessment of fibrosis and steatosis by liver biopsy in alcoholic liver disease patients.

After liver histology assessment for liver liver dammage a potential correlation of fibrosis and steatosis was studied with rs738409 PNPLA3 polymorphism

Data from ClinicalTrials.gov

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