60 elective patients for CABG will be included to receive either standard hyperkalemic cardioplegia (St.Thomas Hospital Solution No I) or cardioplegia where supranormal potassium is replaced with 1.2 mM adenosine. Hypothesis as follows: 1. Adenosine instead of supranormal potassium in the cardioplegic solution give satisfactory cardiac arrest. 2. Adenosine instead of supranormal potassium in the cardioplegic solution gives equal cardioprotection. The patients will be followed with PiCCO-catheter to monitor cardiac function and repetitive blood samples to measure release of cardiac enzymes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
60
1.2 mM adenosine instead of supranormal potassium in the cardioplegic solution
University Hospital of North Norway
Troomsø, Norway
Release of cardiac enzymes (TnT and CKMB)
Repeatedly measured postoperatively.
Time frame: First 48 hour postoperatively
PiCCO
Measurement of cardiac function and hemodynamics the first 24 hours postoperatively
Time frame: First 24 hours postoperatively
Endothelial injury
Measurements of markers of endothelial injury/dysfunction peroperatively. Blood will be sampled immediately before cross-clamping the aorta and after 5 minutes of reperfusion.
Time frame: Peroperatively (before crossclamping aorta and after 5 minutes of reperfusion)
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