Phase I Dose-Escalation Study to Evaluate Tolerability, Safety & PK of INO-8875 in Healthy Older-Adult Volunteers

Inclusion Criteria: * male, or a female with a negative pregnancy test and without childbearing potential * aged 35 to 65 years * body weight is ≥50 kg and ≤115 kg Exclusion Criteria: * Subject has glaucoma or any active ophthalmologic disease including conjunctivitis * Subject has a central retinal vein occlusion in either eye at any time in the past * Subject is currently on any drug that might affect IOP including oral or ocular glucocorticoids or ephedrine * Subject has history of ocular trauma or surgery (except for non-incisional surgery performed at least 3 months prior to the Screening visit) * Subject has a prosthetic eye or any ocular abnormality precluding reliable applanation tonometry in either eye including an immobile pupil. * Subject is not able to refrain from use of contact lenses during the Treatment Period