A Closer Look at the Effect of Dextrose on Postoperative Nausea and Vomiting

Loma Linda University202 enrolled

Overview

"The purpose of this investigator-initiated study is to see if giving dextrose fluid in the veins (IV) decreases the risk of postoperative nausea and vomiting (PONV) in female urologic, gynecologic and breast outpatient surgery patients and at what blood surgery level. The reason for this study is that IV dextrose has been shown to decrease the incidence of PONV and the use of medications to treat PONV, while leading to sooner discharge after surgery. This can decrease overall healthcare cost and improving patient satisfaction."

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

202

Conditions

Postoperative Nausea and Vomiting

Interventions

Intravenous fluidOTHER

The treatment group will receive a 250cc bolus over 2 hrs of D5LR prior to the end of surgery and continued in the PACU. Blood glucose will be checked 3 different times using an Accu-chek monitor along with the type and number of rescue medications given at 30, 60, and 120 minutes after anesthesia and the post-op morning. The control group will receive a 250cc bolus over 2 hours of LR. Blood glucose will be monitored 3 times along with the type and how much of rescue medications are given at 30, 60 and 120 minutes post-op and the morning after surgery.

D5LR or lactated ringersOTHER

The purpose of the study is to see if giving dextrose fluid in the veins (IV) decreases the risk of postoperative nausea and vomiting (PONV) in female urologic, gynecologic and breast outpatient surgery patients and at what blood sugar level. The reason for this study is that IV dextrose may decrease the incidence of PONV and the use of medications to treat PONV, while leading to sooner discharge after surgery. This can decrease overall healthcare cost and improving patient satisfaction.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. ASA I or II 2. female urologic, gynecologic and breast surgery patients undergoing scheduled same day procedures at LLUMC Heart and Surgical Hospital Exclusion Criteria: 1. age \<18 or \>65; 2. severe hypertension,diabetes mellitus, significant hepatic or renal disease 3. excessive blood loss 4. sustained (\>10 min)\>20% from baseline drop in BP after treatment 5. inability to follow protocol 6. refusal to sign consent

Locations (1)

Loma Linda University Medical Center Heart and Surgical Hospital

Loma Linda, California, United States

Outcomes

Primary Outcomes

A Closer Look at the Effect of Glucose on Postoperative Nausea and Vomiting

The primary outcome measures will be the severity and incidence of PONV along with the type and number of rescue medications given at 0,30,60, and 120 minutes PACU time and the next morning.

Time frame: approximately 24 hours

Secondary Outcomes

A Closer Look at the Effect of Dextrose on Post-operative nausea and vomiting

Secondary endpoints recorded will be length of surgery, history of PONV, amount of pain medicine administered, blood loss, drop in BP \> 20%, unplanned hospital admission for PONV, and time till ready for discharge from PACU.

Time frame: approximately 24 hours

Data from ClinicalTrials.gov

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