Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA)

Inclusion Criteria: * Patients aged 18 - 65 * Clinical (pain, fever \> 37.5 °C, WBC \> 10.000 / microL), and ultrasound evidence of cholecystitis * Surgical indication for laparoscopic cholecystectomy * ASA class I-III * Informed consent * \<72 hours from onset of symptoms Exclusion Criteria: * Informed consent refusal * Choledocholithiasis * Pre surgical generalized peritonitis (clinical evaluation) * ASA class \> III * Peripheral artery disease * Active or past history of malignant systemic disease * Pregnant or lactating females * Known allergy to components Floseal including bovine allergy (bovine gelatin) * Known drug or alcohol abuse * Patients with known diabetes, chronic renal disease and other metabolic diseases * Patients in chronic cortisone treatment more than 2 years before surgery * Patients on chronic use of platelet inhibitors such as Aspirin, Plavix, NSAID's etc.