Effects of Atorvastatin on Blood Pressure and Urinary Albumin Excretion

Aristotle University Of Thessaloniki50 enrolled

Overview

To evaluate the possible effects of atorvastatin on ambulatory blood pressure, urinary albumin excretion, insulin resistance and arterial stiffness in hypertensive patients, beyond those on lipid profile. Glycemic parameters, "novel" cardiovascular risk factors and safety parameters will be also evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Hypertension Hypercholesterolemia

Interventions

AtorvastatinDRUG

10 mg of atorvastatin once daily for six months

PlaceboDRUG

placebo once daily for six months

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * LDL-C\>130 or \>160 mg/dL (depending on the total risk according to the most recent recommendations25). * no previous hypolipidemic medication * ability to provide Informed Consent. Exclusion Criteria: * pregnancy or lactation * myocardial infarction or unstable angina within the past 6 months * heart failure NYHA class III-IV * renal disease (SCr\>3 mg/dL or proteinuria\>3g/d) * liver disease * history of malignancy * history of drug or alcohol abuse * treatment with corticosteroids * any other condition with poor prognosis * inability to provide Informed Consent.

Locations (1)

AHEPA University Hospital of Thessaloniki

Thessaloniki, Greece

Outcomes

Primary Outcomes

Ambulatory blood pressure

Time frame: Six months

Secondary Outcomes

Urinary Albumin Excretion

Time frame: Six months

Insulin Sensitivity

Time frame: Six months

Arterial Stiffness

Time frame: Six months

Urinary levels of nephrin

Time frame: Six months

Urinary levels of podocalyxin

Time frame: Six months

Urinary levels of Endothelin-1

Time frame: Six months

Urinary levels of Asymmetric Dimethylarginine

Time frame: Six months

Urinary levels of indices of oxidative stress

Time frame: Six months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.