Trial of Fish Intake Advice in Pregnancy

Harvard Pilgrim Health Care61 enrolled

Overview

The overall goal of this project is to establish a pilot study to develop and refine an intervention to promote consumption of fish low in mercury and high in n-3 PUFA among pregnant women. The investigators will demonstrate our ability to recruit pregnant women, influence their fish consumption, and measure changes in nutrient and toxicant biomarkers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Nutrition

Interventions

Dietary adviceBEHAVIORAL

Dietary advice regarding consumption of low mercury, high DHA fish

ControlBEHAVIORAL

Advice regarding healthful diet during pregnancy, not focused on fish intake

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age 18 years or older * Currently pregnant 12-22 weeks * Singleton pregnancy * Consuming fish \<=2 times per month Exclusion Criteria: * Inability to answer questionnaires in English * Plans to leave study area prior to delivery * Would never eat fish (e.g. vegan, allergy to fish)

Locations (1)

Harvard Pilgrim Health Care

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Plasma elongated n-3 PUFA levels

Change in plasma levels of elongated n-3 PUFA from recruitment to follow up at 12 weeks

Time frame: 12 weeks

Secondary Outcomes

Whole blood mercury

Change in whole blood total mercury level from recruitment to 12 weeks

Time frame: 12 weeks

Fish consumption

Change in fish consumption from recruitment to 12 weeks

Time frame: 12 weeks

Data from ClinicalTrials.gov

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