The purpose of this study is to examine the efficacy of prophylactic antibiotics in patients with chest tubes for management of thoracic injuries in the reduction of the incidence of empyema as compared to placebo.
In this study, the medication (an antibiotic which is used to treat or prevent infections) will be compared with a placebo. A placebo is something that looks like a "real" medication, but it doesn't contain any active medication. As a participant in this study, you may receive the active medication (Cefazolin Sodium Injection or Clindamycin) or you may receive a placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
50
1 gm of Ancef or 300 mg Clindamycin for those who are penicillin allergic
.9% Normal Saline as a placebo
St. Luke's Hospital and Health Network
Bethlehem, Pennsylvania, United States
efficacy of prophylactic antibiotics in reduction of empyema
The primary objective of this study is to examine the efficacy of prophylactic antibiotics in patients with chest tubes for management of thoracic injuries in the reduction of the incidence of empyema as compared to placebo.
Time frame: 30 days
Incidence of Pneumonia and/or development of resistant microorganisms
Secondary objectives include: Incidence of pneumonia Incidence of development of resistant microorganisms
Time frame: 30 days
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