The Effect and Mechanisms of the Second-meal Phenomenon in Type 2 Diabetic Patients

The Catholic University of Korea12 enrolled

Overview

Second-meal phenomenon denotes the effect of a prior meal in decreasing the rise in blood glucose after a subsequent meal. This phenomenon occurs in normal subjects while it is not clear whether it is also observed in type 2 diabetic patients. This study aims to define whether the second-meal phenomenon occurs in type 2 diabetic patients. We will also seek for the mechanism.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Type 2 Diabetes

Eligibility

Sex: ALLMin age: 35 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age 35-70 * HbA1c 6-8% * DM duration less than 5 yrs Exclusion Criteria: * type 1 DM, secondary DM, gestational DM * patients using insulin, TZDs * patients using corticosteroid, herb medication or other medications affecting glucose tolerance * renal dysfunction (Cr \> 1.5mg/dL) * hepatic dysfunction (LFT \> x 3UNL) * anemia (Hg \< 10g/dL) * ischemic heart disease, congestive heart failure * severe diabetic complication (CRF, CVA, PDR, gastroparesis) * infectious disease * malignancy * pregnant women

Locations (1)

St. Vincent's hospital

Suwon, Kyounggi-do, South Korea

Outcomes

Primary Outcomes

Area under the curve of plasma glucose after meal

Compare the post-lunch AUC of glucose between two meal tolerance tests(one after having breakfast, one after not having breakfast)

Time frame: 3 months

Secondary Outcomes

the mechanism of second-meal phenomenon

serum FFA, plasma insulin, C-peptide, incretin concentration will be measured

Time frame: 3 months

Data from ClinicalTrials.gov

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