The aim of this trial is to determine the best dose combination of S-Amlodipine and Telmisartan as compared to monotherapy by assessing the blood pressure lowering effects of a once daily regimen of various combinations of S-Amlodipine and Telmisartan, compared to their monotherapy components and placebo, in patients with stage I or II essential hypertension(a mean seated cuff diastolic blood pressure \>=95 and \<=115 mmHg).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
430
Hallym University Sacred Heart Hospital
Anyang, South Korea
Mean Sitting Diastolic Blood Pressure(MSDBP)
Time frame: After 8 weeks of treatment
Mean Sitting Diastolic Blood Pressure(MSDBP)
Time frame: After 4 weeks of treatment
Mean Sitting Systolic Blood Pressure(MSSBP)
Time frame: After 4 weeks and 8 weeks of treatment
Response rate
Reduction of SBP ≥ 20mmHg, DBP ≥ 10mmHg
Time frame: After 4 weeks and 8 weeks of treatment
Control rate
Reduction SBP \< 140mmHg, DBP \< 90mmHg
Time frame: After 4 weeks and 8 weeks of treatment
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