MIld to MOderate Acute Pancreatitis: Early naSogastric Tube Feeding Compared With pAncreas Rest (MIMOSA)

University of Auckland, New Zealand35 enrolled

Overview

Pain relapse during oral refeeding occurs in at least one-fifth of patients with acute pancreatitis. The study hypothesis is that early administered enteral tube feeding might reduce a risk of pain relapse and shorten the length of hospital stay in patients with acute pancreatitis.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Acute Pancreatitis

Interventions

Enteral tube feedingPROCEDURE

Nasogastric tube feeding started within 24 h of hospital admission

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosis of acute pancreatitis * age 18 years or older * written informed consent Exclusion Criteria: * \> 96 hours after onset of symptoms * \> 24 hours after hospital admission * organ failure by the time of randomization * infectious complications before randomization * received artificial nutrition before randomization * previously enrolled into the trial * chronic pancreatitis * post-ERCP pancreatitis * intraoperative diagnosis of acute pancreatitis * pregnancy * malignancy

Locations (1)

University of Auckland

Auckland, New Zealand

Outcomes

Primary Outcomes

Length of hospital stay

Time frame: Up to 3 months

Secondary Outcomes

Pain relapse

Time frame: Up to 3 months

Local and systemic complications

Time frame: Up to 3 months

Feeding intolerance

Time frame: Up to 3 months

Time to solid oral food tolerated

Time frame: Approx. one week

Pain-free time

Time frame: Up to 3 months

Hospital readmission

Time frame: Up to 6 months

Quality of life

Time frame: Up to 6 months

Mortality

Time frame: Up to 6 months

Data from ClinicalTrials.gov

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