The Evaluation of Bepreve on the Measurement of Wheal and Flare Response From Histamine Skin Prick Testing

Inclusion Criteria: * Healthy male and female subjects, 18 to 65 years of age * Patients must demonstrate a positive reaction to a Histamine skin-prick test. Manifested by a histamine-induced wheal of \>3mm in diameter over the normal saline control after 15 minutes of elapsed time Exclusion Criteria: * Significant signs and symptoms of currently active allergic disease (SAR, perennial allergic rhinitis, episodic allergic rhinitis) * Upper respiratory tract infection, sinusitis, asthma or flu-like symptoms within 2 weeks prior to visit 1 * Subjects who have dermatographism or other skin conditions which might interfere with the interpretation of the skin test results * Subjects who are receiving escalating doses of immunotherapy, oral immunotherapy or short course (rush) immunotherapy * Known hypersensitivity to the investigational product or to drugs with similar chemical properties * Pregnancy and/or breast feeding * Use of antihistamines, NSAIDS, steroids, or other drugs which may affect the skin-response * Use of any medications or agents that are not specified above that may confound the interpretation of the results