The Effect of High PCO2 Solution on Esophageal Acid Sensation

Inclusion Criteria: 10 Healthy Controls * Normal EGD, Normal 24-hr pH * 18-80 Years of age * Able to read, understand and complete study questionnaires and diary * Able to understand study procedures and sign informed consent * Albe to comply with all study requirements 10 NERD (Non-Erosive Reflux Disease) * 18-80 Years of age * Willing to stop PPI/H2 Blocker prior to EGD * Have heartburn symptoms 2+ times per week for at least 3 months. Exclusion Criteria: * Esophageal erosions, Barretts, or peptic stricture on EGD * Previous esophageal, gastric or duodenal surgery * underlying co-morbidities * Diabetes mellitus (requires insulin), scleroderms, or neuromuscular disorder * Upper airway symptoms * Tricyclic antidepressants, antispasmodics, selective serotonin receptor inhibitors, thiazides, bile acid-binding agents or prokinetics * Patients who cannot or are unwilling to sign ICF