Comparison of Nexium Versus Secretol in the Healing and Controlling of Symptoms in GERD Patients With Severe EE.

Inclusion Criteria: * Male or Female * Ages 18-75 * EE Los Angeles grades C or D * Heartburn and/or regurgitation at least 3 times a week during the 7 day run- in period prior to randomization. * Able to read, understand, and complete study questionnaires and record * Able to understand the study procedures and sign informed consent * Able to comply with all study requirements Exclusion Criteria: * Subjects with Barrett's esophagus, non-erosive reflux disease,EE grades A or B, or peptic stricture on endoscopy * Subjects with previous upper gastrointestinal surgery * Subjects with clinically significant underlying comorbidity * Helicobacter pylori positive * Clinically significant GI bleed within the last 3 months * Esophagitis not related to acid reflux * Bleeding disorder * Zollinger-Ellison, achalasia,esophageal varices, duodenal/gastric ulcer, upper gastrointestinal malignancy * Women pregnant or lactating * History of allergic reaction to any Proton Pump Inhibitor (PPI) * Patients can't be treated concurrently with warfarin or other anticoagulants,salicylates,steroids,NSAIDS \> 3 times/week * Any medication dependant on gastric acid for optimal absorption