Gestational diabetes mellitus (GDM)is a major health problem * growing prevalence of obesity * the older age of pregnant women A randomized controlled trial in 54 pregnant voluntary women at high risk for GDM. * feasibility of an early intervention * glucose tolerance at weeks 26-28
1. A 75-g oral glucose tolerance test (OGTT) was performed at weeks 8-12 1. voluntary women in early pregnancy (n=96) 2. 54 high risk mothers were randomized * lifestyle intervention group (n=27) * close follow-up (n=27) 2. An OGTT was performed again at weeks 26-28 * the lifestyle intervention group (n=27) * the close follow-up group (n=27) * other high-risk women of the early care group (n=42)who were not randomized 3. An OGTT was also performed at weeks 26-28 in two neighboring municipalities * a standard care high-risk group(n=171)who did not undergo early intervention 4. Primary outcomes * number of at risk participants developing GDM during pregnancy in the two arms 5. Secondary outcomes * the effect of intervention on fetal growth
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
440
Lifestyle: The women received counseling by a clinical nutritionist six times and by a physiotherapist six times during pregnancy.
Follow-up: The women received information of the results of a glucose tolerance test (OGTT), reported food records three times during pregnancy, exercise history and exercise diaries monthly.
Number of at risk participants developing GDM during pregnancy
The effect of intervention on fetal growth
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