VITdAL@ICU - Correction of Vitamin D Deficiency in Critically Ill Patients

Overview

Study hypothesis: High-dose vitamin D leads to a shorter hospital stay in critically ill patients Vitamin D deficient patients will be randomized to receive either 540,000 IU cholecalciferol or placebo.

Inclusion criteria * Age ≥18 years * expected ICU stay ≥48 hours * vitamin D deficiency: 25(OH)D ≤ 20 ng/ml * feasibility of study drug application via nasogastric tube in cases where oral food intake is not possible Exclusion criteria * moribund patient expected to die within 24 hours * hypercalcaemia (total calcium \>2.65 OR ion. calcium \>1.35 mmol/l) * severely impaired gastrointestinal motility (ileus, residual gastric volume \> 400 ml) * known history of recent kidney stones (≤ 1 year) * known granulomatous diseases (tuberculosis, sarcoidosis) * pregnancy Primary endpoint * hospital stay (hours; starting from ICU admission) Secondary endpoints * percentage of patients with 25(OH)D ≥ 30 ng/ml at day 7 * serum calcium; phosphorus; 25(OH)D; 1,25(OH)D; PTH; osteocalcin; bALP; TRAP; urinary calcium

Conditions

Interventions

Eligibility

Locations (1)

Outcomes