CONDOR Study of Osteonecrosis of the Jaws (TMJ)

Dental Practice-Based Research Network309 enrolled

Overview

The purpose of this study was to examine risk factors for osteonecrosis of the jaw (ONJ), including the possible association with bisphosphonates (BPs). This study used the research infrastructure from the three NIDCR-funded dental practice-based research networks (DPBRN, PEARL, PRECEDENT). De-identified data from the DPBRN were merged with comparable de-identified data from PEARL and PRECEDENT to form a single trans-PBRN data set used for analysis.

The aims of this study were to (1) test the hypothesis that (BP) treatment is a risk factor for (ONJ); (2) to test the hypothesis that dental diseases (particularly periodontal disease), and invasive dental procedures such as dental extractions are true risk factors for (ONJ).

Study Type

OBSERVATIONAL

Enrollment

309

Conditions

Osteonecrosis of the Jaw

Eligibility

Sex: ALLMin age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * participants directly involved in this study were patients of dentists from the dental practice based research networks (DPBRN, PEARL, PRECEDENT). Exclusion Criteria: * participants with a history of sickle cell anemia * participants with a history of external severe trauma to the jaws

Locations (5)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Health Partners Dental Group

Minneapolis, Minnesota, United States

Health Partners Research Foundation

Minneapolis, Minnesota, United States

Kaiser Permanente Center for Health Research

Portland, Oregon, United States

Data from ClinicalTrials.gov

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