Establishment and Characterization of Patient-Derived Non-Small Cell Lung Cancer Xenografts and Cell Cultures

National University Hospital, Singapore

Overview

Xenografts and cell cultures provide sufficient material for analyses at the protein, RNA and DNA level. Patient derived NSCLC xenografts and cell lines are available but none however are Asian in origin. Given the emerging evidence to suggest inter-ethnic differences in NSCLC biology, new models of preclinical drug evaluation should be designed and validated using Asian tumors. Furthermore, such models will allow studies of biological mechanisms of sensitivity and/or resistance and also the study of dynamic regulations under standardized conditions in the Asian context.

Study Type

OBSERVATIONAL

Conditions

Non Small Cell Lung Cancer

Interventions

Xenografts and cell culturesPROCEDURE

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 21 years and above. * Undergoing a surgical resection of tumor as part of clinical management Exclusion Criteria: * Patient or legally acceptable representative unable to provide consent patient in the judgement of the study investigator, is medically unsuitable for this study

Locations (1)

National University Hospital

Singapore, Singapore, Singapore

RECRUITING

Central Contacts

Ross Andrew Soo, MBBS

CONTACT

65 3772 4624 ross_soo@nuhs.edu.sg

Data from ClinicalTrials.gov

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